Ferumoxytol

Pronunciation: FER-ue-MOX-i-tol
Generic Name: Ferumoxytol
Brand Name: Feraheme

Ferumoxytol is used for:

Treating anemia caused by low levels of iron in patients with chronic kidney disease.

Ferumoxytol is an iron replacement product. It works by replacing iron in the body.

Do NOT use Ferumoxytol if:

• you are allergic to any ingredient in Ferumoxytol


• you have high blood iron levels

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ferumoxytol:

Some medical conditions may interact with Ferumoxytol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances (including any iron preparations)


• if you have low blood pressure or anemia that is not caused by low levels of iron


• if you are on dialysis


• if you will be having an MRI (magnetic resonance imaging)

Some MEDICINES MAY INTERACT with Ferumoxytol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Oral iron supplements because their effectiveness may be decreased by Ferumoxytol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ferumoxytol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ferumoxytol:

Use Ferumoxytol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ferumoxytol is given as an injection at your doctor's office, hospital, or clinic. Ask your health care provider any questions you may have about how to use Ferumoxytol.


• Do not use Ferumoxytol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• If you miss a dose of Ferumoxytol, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Ferumoxytol.

Important safety information:

• Ferumoxytol may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Ferumoxytol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Severe and sometimes fatal allergic reactions have occurred in patients using Ferumoxytol. You will be observed for signs of an allergic reaction for at least 30 minutes after you receive Ferumoxytol. Contact your doctor right away if you experience symptoms of an allergic reaction (eg, rash; hives; itching; fainting; trouble breathing; wheezing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness).


• Ferumoxytol may interfere with certain lab tests, including MRIs and tests for iron in the blood. Be sure your doctor and lab personnel know you are using Ferumoxytol.


• Lab and/or medical tests, including blood iron levels, certain blood cell counts, and blood pressure, may be performed while you use Ferumoxytol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Tell your doctor or dentist that you take Ferumoxytol before you receive any medical or dental care, emergency care, or surgery.


• Ferumoxytol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ferumoxytol while you are pregnant. It is not known if Ferumoxytol is found in breast milk. Do not breast-feed while using Ferumoxytol.

Possible side effects of Ferumoxytol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bluish skin or nails; chest, jaw, or left arm pain; fainting; fast or irregular heartbeat; loss of consciousness or unresponsiveness; numbness of an arm or leg; severe or persistent dizziness or light-headedness; shortness of breath; sudden, severe headache or vomiting; swelling at the injection site; swelling of the hands, ankles, legs, or feet; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ferumoxytol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Ferumoxytol:

Ferumoxytol is handled and stored by a health care provider. Keep Ferumoxytol out of the reach of children and away from pets.

General information:

• If you have any questions about Ferumoxytol, please talk with your doctor, pharmacist, or other health care provider.


• Ferumoxytol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ferumoxytol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ferumoxytol resources

• Ferumoxytol Side Effects (in more detail)
• Ferumoxytol Use in Pregnancy & Breastfeeding
• Ferumoxytol Drug Interactions
• Ferumoxytol Support Group
• 0 Reviews for Ferumoxytol - Add your own review/rating

• Ferumoxytol Professional Patient Advice (Wolters Kluwer)


• Ferumoxytol Monograph (AHFS DI)


• ferumoxytol Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Feraheme Prescribing Information (FDA)


• Feraheme Consumer Overview

Compare Ferumoxytol with other medications

• Anemia Associated with Chronic Renal Failure
• Iron Deficiency Anemia

hydroxychloroquine

hye-drox-ee-KLOR-oh-kwin

Oral route(Tablet)

Physicians should completely familiarize themselves with the contents of the leaflet before prescribing hydroxychloroquine .

Commonly used brand name(s)

In the U.S.

• Plaquenil

Available Dosage Forms:

• Tablet

Therapeutic Class: Antimalarial

Chemical Class: Aminoquinoline

Uses For hydroxychloroquine

Hydroxychloroquine belongs to the family of medicines called antiprotozoals. Protozoa are tiny, one-celled animals. Some are parasites that can cause many different kinds of infections in the body.

hydroxychloroquine is used to prevent and to treat malaria and to treat some conditions such as liver disease caused by protozoa. It is also used in the treatment of arthritis to help relieve inflammation, swelling, stiffness, and joint pain and to help control the symptoms of lupus erythematosus (lupus; SLE).

hydroxychloroquine may be given alone or with one or more other medicines. It may also be used for other conditions as determined by your doctor.

Hydroxychloroquine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, hydroxychloroquine is used in certain patients with the following medical conditions:

• Arthritis, juvenile


• Hypercalcemia, sarcoid-associated


• Polymorphous light eruption


• Porphyria cutanea tarda


• Urticaria, solar


• Vasculitis, chronic cutaneous

Before Using hydroxychloroquine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hydroxychloroquine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to hydroxychloroquine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Children are especially sensitive to the effects of hydroxychloroquine. This may increase the chance of side effects during treatment. Overdose is especially dangerous in children. Taking as few as 3 or 4 tablets (250-milligrams [mg] strength) of chloroquine has resulted in death in small children. Because hydroxychloroquine is so similar to chloroquine, it is probably just as toxic.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of hydroxychloroquine in the elderly with use in other age groups.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking hydroxychloroquine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using hydroxychloroquine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Aurothioglucose

Using hydroxychloroquine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Digoxin


• Metoprolol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of hydroxychloroquine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood disease (severe)—Hydroxychloroquine may cause blood disorders

• Eye or vision problems—Hydroxychloroquine may cause serious eye side effects, especially in high doses

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency—Hydroxychloroquine may cause serious blood side effects in patients with this deficiency

• Kidney disease—There may be an increased chance of side effects in patients with kidney disease

• Liver disease—May decrease the removal of hydroxychloroquine from the blood, increasing the chance of side effects

• Nerve or brain disease (severe), including convulsions (seizures)—Hydroxychloroquine may cause muscle weakness and, in high doses, seizures

• Porphyria—Hydroxychloroquine may worsen the symptoms of porphyria

• Psoriasis—Hydroxychloroquine may bring on severe attacks of psoriasis

• Stomach or intestinal disease (severe)—Hydroxychloroquine may cause stomach irritation

Proper Use of hydroxychloroquine

Take hydroxychloroquine with meals or milk to lessen possible stomach upset, unless otherwise directed by your doctor.

Keep hydroxychloroquine out of the reach of children. Children are especially sensitive to the effects of hydroxychloroquine and overdose is especially dangerous in children. Taking as few as 3 or 4 tablets (250-mg strength) of chloroquine has resulted in death in small children. Hydroxychloroquine is probably just as dangerous.

It is very important that you take hydroxychloroquine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of serious side effects.

If you are taking hydroxychloroquine to help keep you from getting malaria, keep taking it for the full time of treatment. If you already have malaria, you should still keep taking hydroxychloroquine for the full time of treatment even if you begin to feel better after a few days. This will help to clear up your infection completely. If you stop taking hydroxychloroquine too soon, your symptoms may return.

Hydroxychloroquine works best when you take it on a regular schedule. For example, if you are to take it once a week to prevent malaria, it is best to take it on the same day each week. Or if you are to take 2 doses a day, 1 dose may be taken with breakfast and the other with the evening meal. Make sure that you do not miss any doses. If you have any questions about this, check with your health care professional.

For patients taking hydroxychloroquine to prevent malaria:

• Your doctor may want you to start taking hydroxychloroquine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria. This will help you to see how you react to the medicine. Also, it will allow time for your doctor to change to another medicine if you have a reaction to hydroxychloroquine.


• Also, you should keep taking hydroxychloroquine while you are in the area and for 4 to 6 weeks after you leave the area. No medicine will protect you completely from malaria. However, to protect you as completely as possible, it is important to keep taking hydroxychloroquine for the full time your doctor ordered. Also, if fever develops during your travels or within 2 months after you leave the area, check with your doctor immediately.

For patients taking hydroxychloroquine for arthritis or lupus:

• hydroxychloroquine must be taken regularly as ordered by your doctor in order for it to help you. It may take up to several weeks before you begin to feel better. It may take up to 6 months before you feel the full benefit of hydroxychloroquine.

For patients unable to swallow hydroxychloroquine tablets:

• Your pharmacist can crush the tablets and put each dose in a capsule. Contents of the capsules may then be mixed with a teaspoonful of jam, jelly, or jello. Be sure you take all the food in order to get the full dose of medicine.

Dosing

The dose of hydroxychloroquine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of hydroxychloroquine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For tablets dosage form:
  
  • For prevention of malaria:
    
    • Adults—400 milligrams (mg) once every seven days.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.4 mg per kilogram (kg) (2.9 mg per pound) of body weight once every seven days.
    
    
  
  
  • For treatment of malaria:
    
    • Adults—800 mg as a single dose. This may sometimes be followed by a dose of 400 mg six to eight hours after the first dose, then 400 mg once a day on the second and third days.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 32 mg per kg (14.5 mg per pound) of body weight taken over a period of three days.
    
    
  
  
  • For treatment of arthritis:
    
    • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 6.5 mg per kg (2.9 mg per pound) of body weight per day.
    
    
  
  

Missed Dose

If you miss a dose of hydroxychloroquine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using hydroxychloroquine

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after long-term treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms do not improve within a few days (or a few weeks or months for arthritis), or if they become worse, check with your doctor.

Hydroxychloroquine may cause blurred vision, difficulty in reading, or other change in vision. It may also cause some people to become dizzy or lightheaded. Make sure you know how you react to hydroxychloroquine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. If these reactions are especially bothersome, check with your doctor.

Malaria is spread by mosquitoes. If you are living in, or will be traveling to, an area where there is a chance of getting malaria, the following mosquito-control measures will help to prevent infection:

• If possible, sleep under mosquito netting to avoid being bitten by malaria-carrying mosquitoes.


• Wear long-sleeved shirts or blouses and long trousers to protect your arms and legs, especially from dusk through dawn when mosquitoes are out.


• Apply mosquito repellent to uncovered areas of the skin from dusk through dawn when mosquitoes are out.

hydroxychloroquine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. When hydroxychloroquine is used for short periods of time, side effects usually are rare. However, when it is used for a long time and/or in high doses, side effects are more likely to occur and may be serious.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Blurred vision or any other change in vision—this side effect may also occur or get worse after you stop taking hydroxychloroquine

Rare

• Convulsions (seizures)


• increased muscle weakness


• mood or other mental changes


• ringing or buzzing in ears or any loss of hearing


• sore throat and fever


• unusual bleeding or bruising


• unusual tiredness


• weakness

Symptoms of overdose

• Drowsiness


• headache


• increased excitability

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• difficulty in seeing to read


• headache


• itching (more common in black patients)


• loss of appetite


• nausea or vomiting


• stomach cramps or pain

Less common

• Bleaching of hair or increased hair loss


• blue-black discoloration of skin, fingernails, or inside of mouth


• dizziness or lightheadedness


• nervousness or restlessness


• skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: hydroxychloroquine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More hydroxychloroquine resources

• Hydroxychloroquine Side Effects (in more detail)
• Hydroxychloroquine Dosage
• Hydroxychloroquine Use in Pregnancy & Breastfeeding
• Drug Images
• Hydroxychloroquine Drug Interactions
• Hydroxychloroquine Support Group
• 50 Reviews for Hydroxychloroquine - Add your own review/rating

• hydroxychloroquine Concise Consumer Information (Cerner Multum)


• Hydroxychloroquine MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydroxychloroquine Sulfate Monograph (AHFS DI)

Compare hydroxychloroquine with other medications

• Dermatomyositis
• Lyme Disease, Arthritis
• Malaria
• Malaria Prevention
• Rheumatoid Arthritis
• Sjogren's Syndrome
• Systemic Lupus Erythematosus
• Undifferentiated Connective Tissue Disease

Estrace Vaginal local

Generic Name: estradiol vaginal (local) (ess tra DYE ole VAJ in ul (LO kul))

Brand Names: Estrace Vaginal, Estring, Vagifem

What is estradiol vaginal (local)?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Estradiol vaginal (local) is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol vaginal also reduces urgency or irritation of urination.

Estradiol vaginal (local) may also be used for purposes not listed in this medication guide.

What is the most important information I should know about estradiol vaginal (local)?

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms involving the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is placed or applied.

The information in this leaflet is specific to estradiol vaginal products that are used for local treatment of symptoms.

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol vaginal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol.

What should I discuss with my healthcare provider before using estradiol vaginal (local)?

You should not use estradiol vaginal if you have:

• 
  

  a bleeding or blood-clotting disorder;

  
  


• 
  

  a history of stroke or circulation problems;

  
  


• 
  

  abnormal vaginal bleeding that a doctor has not checked; or

  
  


• 
  

  any type of breast, uterine, or hormone-dependent cancer.

  
  

To make sure you can safely use estradiol vaginal, tell your doctor if you have any of these other conditions:

• 
  

  high blood pressure, angina, or heart disease;

  
  


• 
  

  high cholesterol or triglycerides;

  
  


• liver disease;


• kidney disease;


• 
  

  asthma;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  migraines;

  
  


• 
  

  diabetes;

  
  


• 
  

  depression;

  
  


• 
  

  gallbladder disease; or

  
  


• 
  

  if you have had your uterus removed (hysterectomy).

  
  

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol vaginal.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use estradiol vaginal if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Estradiol may decrease breast milk flow and have other effects on milk composition. Do not use estradiol without first talking to your doctor if you are breast-feeding a baby.

How should I use estradiol vaginal (local)?

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms involving the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is placed or applied.

The information in this leaflet is specific to estradiol vaginal products that are used for local treatment of symptoms.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

To use the estradiol vaginal ring:

• 
  

  Squeeze the sides of the ring together and insert it into the vagina as far as possible. You should not be able to feel the ring once it is in place. If you can feel it, use a finger to push it in farther. It is not possible for the ring to go too far in or become lost.

  
  


• 
  

  Leave the ring in place for 90 days. If the ring ever falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to push it in farther. After 90 days, remove the ring. Your doctor may want you to replace it with a new ring.

  
  


• 
  

  The ring does not need to be removed during sexual intercourse. Neither partner should be able to feel the ring when it is in place. If the ring is bothersome, you may remove it, rinse it with warm water, and reinsert it after intercourse.

  
  


• 
  

  To remove the ring, loop a finger through the ring and gently pull it from the vagina.

  
  

To use the estradiol vaginal cream:

• 
  

  Using the marked applicator provided, measure the prescribed dose of cream.

  
  


• 
  

  Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. Gently insert the applicator deep into your vagina and press in the plunger to empty the cream from the applicator into the vagina.

  
  


• 
  

  Take apart the applicator and wash it with mild soap and warm water. Allow the applicator to dry completely before using it again.

  
  

To use the estradiol vaginal tablets:

• 
  

  Each vaginal tablet is supplied in a disposable applicator.

  
  


• 
  

  Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. Gently insert the applicator deep into your vagina and press in the plunger to empty the tablet into the vagina.

  
  


• 
  

  Throw the applicator away.

  
  

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol vaginal.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

If a vaginal ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to push it in farther.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while using estradiol vaginal (local)?

Avoid using other vaginal products without your doctor's advice.

Estradiol vaginal (local) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  pain, swelling, warmth, or redness in one or both legs;

  
  


• 
  

  abnormal vaginal bleeding;

  
  


• 
  

  pain, swelling, or tenderness in your stomach;

  
  


• 
  

  jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  a lump in your breast.

  
  

Less serious side effects may include:

• 
  

  nausea, vomiting, loss of appetite;

  
  


• 
  

  swollen breasts;

  
  


• 
  

  acne or skin color changes;

  
  


• 
  

  decreased sex drive, impotence, or difficulty having an orgasm;

  
  


• 
  

  migraine headaches or dizziness;

  
  


• 
  

  vaginal pain, dryness, or discomfort;

  
  


• 
  

  swelling of your ankles or feet;

  
  


• 
  

  depression; or

  
  


• 
  

  changes in your menstrual periods, break-through bleeding.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estradiol vaginal (local)?

Tell your doctor about all other medicines you use, especially:

• 
  

  St. John's wort;

  
  


• 
  

  phenobarbital (Solfoton);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


• 
  

  ritonavir (Norvir, Kaletra);

  
  


• 
  

  carbamazepine (Carbatrol, Tegretol);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole); or

  
  


• 
  

  antifungal medicine such as antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend).

  
  

This list is not complete and other drugs may interact with estradiol vaginal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Estrace Vaginal resources

• Estrace Vaginal Side Effects (in more detail)
• Estrace Vaginal Use in Pregnancy & Breastfeeding
• Estrace Vaginal Drug Interactions
• Estrace Vaginal Support Group
• 12 Reviews for Estrace Vaginal - Add your own review/rating

Compare Estrace Vaginal with other medications

• Atrophic Urethritis
• Atrophic Vaginitis
• Hypoestrogenism

Where can I get more information?

• Your pharmacist can provide more information about estradiol vaginal (local).

See also: Estrace Vaginal side effects (in more detail)

Irbesartan

In the US, Irbesartan (irbesartan systemic) is a member of the drug class angiotensin II inhibitors and is used to treat Diabetic Kidney Disease and High Blood Pressure.

US matches:

• Irbesartan


• Irbesartan/Hydrochlorothiazide

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

C09CA04

CAS registry number (Chemical Abstracts Service)

0138402-11-6

Chemical Formula

C25-H28-N6-O

Molecular Weight

428

Therapeutic Categories

Antihypertensive agent

Angiotensin-II antagonist

Chemical Name

1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Foreign Names

• Irbesartanum (Latin)
• Irbesartan (German)
• Irbesartan (French)
• Irbesartan (Spanish)

Generic Names

• Irbesartan (OS: USAN, BAN)
• BMS 186295 (IS: Bristol-Myers)
• SR 47436 (IS: SanofiWinthrop)
• Irbesartan (PH: USP 32)

Brand Names

• Adana
  Sandoz, Argentina



• Aprovel
  Bristol-Myers Squibb, United Kingdom; Bristol-Myers Squibb, Iceland; Bristol-Myers Squibb, Portugal; Bristol-Myers Squibb, Romania; Sanofi, Luxembourg; Sanofi, Tunisia; Sanofi Aventis, Antigua & Barbuda; Sanofi Aventis, Netherlands Antilles; Sanofi Aventis, Aruba; Sanofi Aventis, Bermuda; Sanofi Aventis, Bahamas; Sanofi Aventis, China; Sanofi Aventis, Haiti; Sanofi Aventis, Jamaica; Sanofi Aventis, Cayman Islands; Sanofi Aventis, Saint Lucia; Sanofi Aventis, Trinidad & Tobago; Sanofi Aventis, Saint Vincent & The Grenadines; Sanofi Pharma, Denmark; Sanofi Pharma Bristol-Myers Squibb, Norway; Sanofi Winthrop, Bulgaria; Sanofi/Bristol-Myers Squibb, Switzerland; Sanofi-Aventis, Argentina; Sanofi-Aventis, Belgium; Sanofi-Aventis, Bahrain; Sanofi-Aventis, Brazil; Sanofi-Aventis, Belize; Sanofi-Aventis, Chile; Sanofi-Aventis, Colombia; Sanofi-Aventis, Costa Rica; Sanofi-Aventis, Germany; Sanofi-Aventis, Dominican Republic; Sanofi-Aventis, Ecuador; Sanofi-Aventis, France; Sanofi-Aventis, United Kingdom; Sanofi-Aventis, Greece; Sanofi-Aventis, Guatemala; Sanofi-Aventis, Hong Kong; Sanofi-Aventis, Honduras; Sanofi-Aventis, Croatia (Hrvatska); Sanofi-Aventis, Hungary; Sanofi-Aventis, Indonesia; Sanofi-Aventis, Ireland; Sanofi-Aventis, Iceland; Sanofi-Aventis, Italy; Sanofi-Aventis, Mexico; Sanofi-Aventis, Malaysia; Sanofi-Aventis, Nicaragua; Sanofi-Aventis, Netherlands; Sanofi-Aventis, Oman; Sanofi-Aventis, Panama; Sanofi-Aventis, Peru; Sanofi-Aventis, Philippines; Sanofi-Aventis, Romania; Sanofi-Aventis, Russian Federation; Sanofi-Aventis, Sweden; Sanofi-Aventis, Singapore; Sanofi-Aventis, Slovenia; Sanofi-Aventis, Slovakia; Sanofi-Aventis, El Salvador; Sanofi-Aventis, Thailand; Sanofi-Aventis, Taiwan; Sanofi-Aventis, Venezuela; Sanofi-Aventis, Vietnam; Sanofi-Aventis, South Africa; Sanofi-Aventis S.A.U., Spain; Sanofi-Synthelabo, Myanmar; Sanofi-Synthelabo, Portugal



• Arbit
  Beximco, Bangladesh



• Avalide (Irbesartan and Hydrochlorothiazide)
  Bristol-Myers Squibb, Canada; Bristol-Myers Squibb, United States; sanofi-aventis, Canada; sanofi-aventis, United States



• Avapro
  Bristol-Myers Squibb, Argentina; Bristol-Myers Squibb, Australia; Bristol-Myers Squibb, Brazil; Bristol-Myers Squibb, Canada; Bristol-Myers Squibb, Mexico; Bristol-Myers Squibb, United States; Dainippon Sumitomo, Japan; Sanofi-Aventis, United States



• Cavapro
  Unimed & Unihealth, Bangladesh



• Co Aprovel (Irbesartan and Hydrochlorothiazide)
  Sanofi-Aventis, Belgium; Sanofi-Aventis, Peru



• CoAprovel (Irbesartan and Hydrochlorothiazide)
  Bristol-Myers Squibb, France; Bristol-Myers Squibb, United Kingdom; Sanofi, Tunisia; Sanofi Aventis, China; Sanofi Pharma Bristol-Myers Squibb, Norway; Sanofi Winthrop, Bulgaria; Sanofi/Bristol-Myers Squibb, Switzerland; Sanofi-Aventis, Bahrain; Sanofi-Aventis, Germany; Sanofi-Aventis, Denmark; Sanofi-Aventis, United Kingdom; Sanofi-Aventis, Croatia (Hrvatska); Sanofi-Aventis, Hungary; Sanofi-Aventis, Indonesia; Sanofi-Aventis, Ireland; Sanofi-Aventis, Italy; Sanofi-Aventis, Netherlands; Sanofi-Aventis, Oman; Sanofi-Aventis, Sweden; Sanofi-Aventis, Singapore; Sanofi-Aventis, Slovenia; Sanofi-Aventis, Slovakia; Sanofi-Aventis, Thailand; Sanofi-Aventis, South Africa; Sanofi-Aventis S.A.U., Spain; Sanofi-Synthelabo, Bulgaria



• Ecard
  Jayson, Bangladesh



• Fritens
  Kalbe, Indonesia



• Ibsan
  Acme, Bangladesh



• Irbehasan 150/300
  Hasan, Vietnam



• Irbeprex
  Gotland, Colombia



• Irbes
  Eskayef, Bangladesh



• Irbesartan Caferma
  Caferma, Peru



• Irbesartan Grey Inversiones
  Grey Inversiones, Peru



• Irbesartan Krka
  Krka, Slovakia



• Irbesartan Miklich
  krka, Bulgaria



• Irbesartan Sandoz
  Sandoz, Switzerland; Sandoz, Colombia; Sandoz, Costa Rica; Sandoz, Guatemala; Sandoz, Nicaragua; Sandoz, Panama; Sandoz, El Salvador



• Irbesartan
  Stada, Vietnam



• Irbesel
  Caferma, Peru



• Irbetan
  Shionogi Seiyaku, Japan



• Irbett
  Metlen, Colombia



• Irda
  Nobel, Turkey



• Iretensa
  Fahrenheit, Indonesia



• Irovel
  Sun, India



• Irtan Plus (Irbesartan and Hydrochlorothiazide)
  Ikapharmindo, Indonesia



• Irtan
  Ikapharmindo, Indonesia



• Irvask
  Kalbe, Indonesia



• Irvell
  Novell, Indonesia



• Isart
  ACI, Bangladesh



• Karvea
  Bristol-Myers Squibb, Germany; Bristol-Myers Squibb, Spain; Bristol-Myers Squibb, Greece; Bristol-Myers Squibb, Italy; Sanofi-Aventis, Australia; Sanofi-Aventis, Turkey



• Karvera
  Sanofi-Aventis, New Zealand



• Karvezide (Irbesartan and Hydrochlorothiazide)
  Bristol-Myers Squibb, Germany; Bristol-Myers Squibb, Spain; Bristol-Myers Squibb, Greece; Bristol-Myers Squibb, Italy; Brystol-Myers Squbb, Slovakia; Sanofi-Aventis, Australia



• Presartan
  Dr. Collado, Dominican Republic

International Drug Name Search

Glossary

BAN	British Approved Name
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Inistolin Pediatrico Expectorante

Inistolin Pediatrico Expectorante may be available in the countries listed below.

Ingredient matches for Inistolin Pediatrico Expectorante

Guaifenesin

Guaifenesin is reported as an ingredient of Inistolin Pediatrico Expectorante in the following countries:

• Spain

Pseudoephedrine

Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Inistolin Pediatrico Expectorante in the following countries:

• Spain

International Drug Name Search

Indometacin Tabl.

Indometacin Tabl. may be available in the countries listed below.

Ingredient matches for Indometacin Tabl.

Indometacin

Indometacin is reported as an ingredient of Indometacin Tabl. in the following countries:

• Georgia

International Drug Name Search

Aurothioglucose

Generic Name: Aurothioglucose (aur-oh-thye-oh-GLOO-kose)
Brand Name: Generic only. No brands available.

Aurothioglucose contains gold, which can build up in the blood and cause toxic reactions. Report any symptom suggesting toxicity (rash, mouth sores, persistent diarrhea, indigestion, metallic taste, unusual bleeding or bruising, itching, blood in the urine, fainting) to your health care provider immediately.

Aurothioglucose is used for:

Treating rheumatoid arthritis that cannot be adequately controlled by other medicines. Aurothioglucose is used in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Aurothioglucose is an antirheumatic agent. It works by suppressing or preventing swelling and slowing cartilage and bone destruction.

Do NOT use Aurothioglucose if:

• you are allergic to any ingredient in Aurothioglucose


• you have developed severe toxicity from previous exposure to gold or other heavy metals


• you are taking penicillamine


• you have a blood or bleeding disorder

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aurothioglucose:

Some medical conditions may interact with Aurothioglucose. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have small red spots under the skin, unusual bleeding and bruising, eczema, liver disease, kidney problems, lupus, yellowing of the skin or eyes, inflammation of the skin or mouth, blood circulation problems, chronic arthritis accompanied by dry mouth/eyes, itching, skin rash, or colitis


• if you are debilitated or have recently received radiation therapy

Some MEDICINES MAY INTERACT with Aurothioglucose. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Penicillamine because the risk of serious blood or kidney problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aurothioglucose may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aurothioglucose:

Use Aurothioglucose as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aurothioglucose is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Aurothioglucose at home, carefully follow the injection procedures taught to you by your health care provider.


• If Aurothioglucose contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Aurothioglucose, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Aurothioglucose.

Important safety information:

• Three to six months may pass before you feel the full effect of Aurothioglucose. Continue receiving injections during this time.


• Joint pain may be worse for 1 or 2 days after your injection, but it should end after the first few injections.


• Aurothioglucose may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Aurothioglucose. Use a sunscreen or protective clothing if you must be outside for a prolonged period.


• After you receive an injection, you may experience flushing, dizziness, or sweating. If you lie down for a few minutes, these effects will usually disappear. If they continue, check with your doctor.


• LAB TESTS, including complete blood cell counts, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.


• Aurothioglucose is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Aurothioglucose during pregnancy. Aurothioglucose is excreted in breast milk. Do not breast-feed while taking Aurothioglucose.

Possible side effects of Aurothioglucose:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in heartbeat; changes in skin color; cough; diarrhea; dizziness; fever; flushing; gas; gum disease; hives; nausea; purple blotches or other skin spots; rash; shortness of breath; skin inflammation; sore throat; unusual weakness; upper respiratory tract infection; vaginal infection; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding problems; blood in the urine; changes in heartbeat; fainting; indigestion; itching; metallic taste; mouth sores; persistent diarrhea; unusual bleeding or bruising; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aurothioglucose side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fever; hives; nausea; severe itching; vomiting.

Proper storage of Aurothioglucose:

Store Aurothioglucose below 86 degrees F (30 degrees C). Do not freeze. Protect from light. Store in carton until contents are used. Do not store in the bathroom. Keep Aurothioglucose out of the reach of children and away from pets.

General information:

• If you have any questions about Aurothioglucose, please talk with your doctor, pharmacist, or other health care provider.


• Aurothioglucose is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aurothioglucose. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aurothioglucose resources

• Aurothioglucose Side Effects (in more detail)
• Aurothioglucose Use in Pregnancy & Breastfeeding
• Aurothioglucose Drug Interactions
• Aurothioglucose Support Group
• 0 Reviews for Aurothioglucose - Add your own review/rating

• aurothioglucose Concise Consumer Information (Cerner Multum)


• Solganal Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Aurothioglucose with other medications

• Pemphigus
• Psoriatic Arthritis
• Rheumatoid Arthritis

Cortomycin

Generic Name: hydrocortisone, neomycin, and polymyxin B otic (HYE droe KOR ti sone, NEE oh MYE sin, POL ee MIX in B)

Brand Names: Cort-Biotic, Cortatrigen, Cortatrigen Modified, Cortisporin Otic, Cortomycin, Oti-Sone, Pediotic

What is Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

Hydrocortisone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Neomycin and polymyxin B are antibiotics that fight bacteria.

The combination of hydrocortisone, neomycin, and polymyxin B otic (for the ears) is used to treat ear infections caused by bacteria.

This medication will not treat a viral infection such as herpes or shingles.

Hydrocortisone, neomycin, and polymyxin B otic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

You should not use this medication if you are allergic to hydrocortisone, neomycin, or polymyxin B, or if you have a ruptured ear drum, or an ear infection caused by chickenpox, or herpes infection (simplex or zoster).

Before using this medication, tell your doctor if you have herpes (simplex or zoster), chickenpox or small pox, any ear infection that causes blistering, asthma or sulfite allergy, or if you are allergic to an antibiotic similar to neomycin, such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), netilmicin (Netromycin), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Talk with your doctor if your symptoms do not improve after 1 week of using this medication.

Do not use this medication for longer than 10 days in a row unless your doctor tells you to. Long-term use of neomycin may cause damage to your hearing. Stop using this medication and call your doctor at once if you have skin rash, redness, swelling, itching, dryness, scaling, severe burning or stinging, or other irritation in or around the ear. Other serious side effects include new signs of infection, hearing loss, or urinating less than usual or not at all.

What should I discuss with my health care provider before using Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

You should not use this medication if you are allergic to hydrocortisone, neomycin, or polymyxin B, or if you have:

• 
  

  a ruptured ear drum; or

  
  


• 
  

  an ear infection caused by chickenpox, or herpes infection (simplex or zoster).

  
  

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• 
  

  herpes (simplex or zoster);

  
  


• 
  

  chickenpox or small pox;

  
  


• 
  

  any ear infection that causes blistering;

  
  


• 
  

  asthma or sulfite allergy; or

  
  


• 
  

  if you are allergic to an antibiotic similar to neomycin, such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), netilmicin (Netromycin), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).

  
  

FDA pregnancy category C. It is not known whether hydrocortisone, neomycin, and polymyxin B otic ear drops are harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Hydrocortisone and colistin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication in a child younger than 2 years old.

How should I use Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Before using this medication, clean and dry your ear canal with sterile cotton.

Shake the ear drops well just before you measure a dose.

This medication is usually given as 4 to 5 drops into the affected ear every 6 to 8 hours. Children may need to use fewer drops. Follow your doctor's instructions about how much medication you should use and how often.

Do not use this medication for longer than 10 days in a row unless your doctor tells you to. Long-term use of neomycin may cause damage to your hearing.

To use the ear drops, first remove the cap from the dropper bottle. Lie down or tilt your head with your ear facing upward. Pull back on your ear gently to open up the ear canal. If giving this medicine to a child, pull down on the earlobe to open the ear canal. Hold the dropper upside down over the ear canal and drop the correct number of drops into the ear.

Do not place the dropper tip into your ear or allow the tip to touch any surface. It may become contaminated.

After using the ear drops, stay lying down or with your head tilted for at least 5 minutes.

As an alternative to dropping the medicine into your ear, you may insert a small piece of cotton into the ear canal and then drop the medicine directly onto the cotton to soak it. Leave the cotton in the ear and keep it moist by adding more of the medication every 4 to 8 hours. Replace the cotton at least every 24 hours. Follow your doctor's instructions about the use of cotton with this medication.

Wipe the ear dropper tip with a clean tissue. Do not wash the tip with water or soap.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Talk with your doctor if your symptoms do not improve after 1 week of using this medication.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include hearing problems, or urinating less than usual.

What should I avoid while using Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

Avoid getting this medication in your eyes. If this does happen, rinse with water.

Cortomycin (hydrocortisone, neomycin, and polymyxin B otic) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  skin rash, redness, swelling, itching, dryness, scaling, or other irritation in or around the ear;

  
  


• 
  

  severe burning, stinging, or other irritation when using the medication;

  
  


• 
  

  new signs of infection;

  
  


• 
  

  hearing loss; or

  
  


• 
  

  urinating less than usual or not at all.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cortomycin (hydrocortisone, neomycin, and polymyxin B otic)?

It is not likely that other drugs you take orally or inject will have an effect on hydrocortisone, neomycin, and polymyxin B used in the ears. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Cortomycin resources

• Cortomycin Side Effects (in more detail)
• Cortomycin Use in Pregnancy & Breastfeeding
• Cortomycin Drug Interactions
• Cortomycin Support Group
• 0 Reviews for Cortomycin - Add your own review/rating

• Cortomycin Prescribing Information (FDA)


• Cortomycin Advanced Consumer (Micromedex) - Includes Dosage Information


• Cortomycin Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Pediotic Prescribing Information (FDA)

Compare Cortomycin with other medications

• Otitis Externa
• Otitis Media

Where can I get more information?

• Your pharmacist can provide more information about hydrocortisone, neomycin, and polymyxin B otic.

See also: Cortomycin side effects (in more detail)

Morrhuate

Pronunciation: MOR-yoo-ate
Generic Name: Morrhuate
Brand Name: Scleromate

Morrhuate is used for:

Treating varicose veins.

Morrhuate is a mixture of saturated and unsaturated fatty acids. It works by causing inflammation of the inside of the injected vein and creating a blood clot, which results in the destruction of the vein.

Do NOT use Morrhuate if:

• you are allergic to any ingredient in Morrhuate


• you have an infection of the blood, tuberculosis (TB), or any other infection


• you have a blood clot in the veins (deep vein thrombosis), blood problems, skin problems, a blockage in your blood vessels, inflammation of your veins, tumors, cancer, or varicose veins caused by unusual growths or tumors in your abdominal or pelvic area


• you have asthma, a severely overactive thyroid, or uncontrolled diabetes

Contact your doctor or health care provider right away if any of these apply to you.

Before using Morrhuate:

Some medical conditions may interact with Morrhuate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Morrhuate. However, no specific interactions with Morrhuate are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Morrhuate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Morrhuate:

Use Morrhuate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Morrhuate is usually administered as an injection at your doctor's office, hospital, or clinic.


• If Morrhuate contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• If you miss a dose of Morrhuate, contact your doctor.

Ask your health care provider any questions you may have about how to use Morrhuate.

Important safety information:

• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, discuss with your doctor the benefits and risks of using Morrhuate during pregnancy. If you are or will be breast-feeding while you are using Morrhuate, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Morrhuate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Aching; burning, cramping, discoloration (light bronze color), or a sensation of stiffness around the injection area.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); pain, redness, or swelling around the injection site; skin ulceration.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Morrhuate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Morrhuate:

Store Morrhuate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Morrhuate out of the reach of children and away from pets.

General information:

• If you have any questions about Morrhuate, please talk with your doctor, pharmacist, or other health care provider.


• Morrhuate is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Morrhuate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Morrhuate resources

• Morrhuate Side Effects (in more detail)
• Morrhuate Use in Pregnancy & Breastfeeding
• Morrhuate Support Group
• 0 Reviews for Morrhuate - Add your own review/rating

Compare Morrhuate with other medications

• Varicose Veins

Prevnar 13

Generic Name: pneumococcal 13-valent conjugate vaccine (NOO moe KOK al 13-VAY lent KON joo gate VAX een)

Brand Names: Prevnar 13

What is pneumococcal 13-valent conjugate vaccine?

Pneumococcal disease is a serious infection caused by a bacteria. Pneumococcal bacteria can infect the sinuses and inner ear. It can also infect the lungs, blood, and brain, and these conditions can be fatal.

Pneumococcal 13-valent vaccine is used to prevent infection caused by pneumococcal bacteria. This vaccine contains 13 different types of pneumococcal bacteria.

Pneumococcal 13-valent vaccine works by exposing you to a small amount of the bacteria or a protein from the bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Pneumococcal 13-valent vaccine is for use in children from 6 weeks to 5 years old, and in adults who are 50 and older.

Becoming infected with pneumococcal disease (such as pneumonia or meningitis) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Like any vaccine, pneumococcal 13-valent vaccine may not provide protection from disease in every person.

What is the most important information I should know about this vaccine?

For children, the pneumococcal 13-valent vaccine is given in a series of shots. The first shot is usually given when the child is 2 months old. The booster shots are then given at 4 months, 6 months, and 12 to 15 months of age. Adults usually receive only one dose of the vaccine.

In a child older than 6 months who has not yet received this vaccine, the first dose can be given any time from the age of 7 months through 5 years (before the 6th birthday).

If the child is less than 1 year old at the time of the first shot, he or she will need 2 booster doses. If the child is 12 to 23 months old at the time of the first shot, he or she will need 1 booster dose. A child who is 2 years or older at the time of the first shot may need only the one shot and no booster doses.

The timing of this vaccination is very important for it to be effective. Your child's individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in. Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

Becoming infected with pneumococcal disease (such as pneumonia or meningitis) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Be sure to keep your child on a regular schedule for other immunizations against diseases such as diphtheria, tetanus, pertussis (whooping cough), measles, mumps, hepatitis, or varicella (chicken pox). Your doctor or state health department can provide you with a recommended immunization schedule.

What should I discuss with my healthcare provider before receiving this vaccine?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. You should not receive this vaccine if you ever had a severe allergic reaction to a pneumococcal or diphtheria vaccine.

Before your child receives this vaccine, tell your doctor if the child was born prematurely.

To make sure you or your child can safely receive this vaccine, tell your doctor if you or your child have any of these other conditions:

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  a bleeding or blood clotting disorder such as hemophilia or easy bruising; or

  
  


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  a weak immune system caused by disease, bone marrow transplant, or by using certain medicines or receiving cancer treatments.

  
  

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

How is this vaccine given?

This vaccine is injected into a muscle. You will receive this injection in a doctor's office or clinic setting.

For children, the pneumococcal 13-valent vaccine is given in a series of shots. The first shot is usually given when the child is 2 months old. The booster shots are then given at 4 months, 6 months, and 12 to 15 months of age. Adults usually receive only one dose of the vaccine.

The first injection should be given no earlier than 6 weeks of age. Allow at least 2 months to pass between injections.

If your child is older than 6 months, he or she can still receive this vaccine on the following schedule:

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  Age 7-11 months: two injections at least 4 weeks apart, followed by a third injection after the child turns 1 year (at least 2 months after the second injection);

  
  


• 
  

  Age 12-23 months: two injections at least 2 months apart;

  
  


• 
  

  Age 24 months to 5 years (before the 6th birthday): one injection.

  
  

The timing of this vaccination is very important for it to be effective. Your child's individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Your doctor may recommend treating fever and pain with an aspirin-free pain reliever such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil, and others) when the shot is given and for the next 24 hours. Follow the label directions or your doctor's instructions about how much of this medicine to give your child.

It is especially important to prevent fever from occurring in a child who has a seizure disorder such as epilepsy.

Be sure to keep your child on a regular schedule for other immunizations such as diphtheria, tetanus, pertussis (whooping cough), hepatitis, and varicella (chicken pox). Your doctor or state health department can provide you with a recommended immunization schedule.

What happens if I miss a dose?

Contact your doctor if your child will miss a booster dose or gets behind schedule. The next dose should be given as soon as possible. There is no need to start over.

Be sure your child receives all recommended doses of this vaccine. If your child does not receive the full series of vaccines, he or she may not be fully protected against the disease.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid before or after receiving this vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

This vaccine side effects

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot. Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat. Call your doctor at once if you or your child has a serious side effect such as:

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  high fever (103 degrees or higher);

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  wheezing, trouble breathing;

  
  


• 
  

  severe stomach pain, severe vomiting or diarrhea;

  
  


• 
  

  easy bruising or bleeding; or

  
  


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  severe pain, itching, irritation, or skin changes where the shot was given.

  
  

Less serious side effects include

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  crying, fussiness;

  
  


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  headache, tired feeling;

  
  


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  muscle or joint pain;

  
  


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  drowsiness, sleeping more or less than usual;

  
  


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  mild redness, swelling, tenderness, or a hard lump where the shot was given;

  
  


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  loss of appetite, mild vomiting or diarrhea;

  
  


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  low fever (102 degrees or less), chills; or

  
  


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  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What other drugs will affect this vaccine?

Before receiving this vaccine, tell the doctor about all other vaccines you or your child have recently received.

Also tell the doctor if you or your child have recently received drugs or treatments that can weaken the immune system, including:

• 
  

  an oral, nasal, inhaled, or injectable steroid medicine;

  
  


• 
  

  chemotherapy or radiation;

  
  


• 
  

  medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders, such as azathioprine (Imuran), etanercept (Enbrel), leflunomide (Arava), and others; or

  
  


• 
  

  medicines to treat or prevent organ transplant rejection, such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab CD3 (Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).

  
  

If you are using any of these medications, you may not be able to receive the vaccine, or may need to wait until the other treatments are finished.

There may be other drugs that can interact with pneumococcal 13-valent vaccine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Prevnar 13 resources

• Prevnar 13 Side Effects (in more detail)
• Prevnar 13 Use in Pregnancy & Breastfeeding
• Prevnar 13 Drug Interactions
• Prevnar 13 Support Group
• 0 Reviews for Prevnar3 - Add your own review/rating

• Prevnar 13 Prescribing Information (FDA)


• Prevnar 13 Advanced Consumer (Micromedex) - Includes Dosage Information


• Prevnar 13 MedFacts Consumer Leaflet (Wolters Kluwer)


• Prevnar 13 Consumer Overview

Compare Prevnar 13 with other medications

• Pneumococcal Disease Prophylaxis

Where can I get more information?

• Your doctor or pharmacist can provide more information about this vaccine. Additional information is available from your local health department or the Centers for Disease Control and Prevention.

See also: Prevnar3 side effects (in more detail)

Gonadorelin 100 micrograms powder and solvent for solution for injection

1. Name Of The Medicinal Product

Gonadorelin 100 micrograms powder and solvent for solution for injection

HRF 100 microgram

2. Qualitative And Quantitative Composition

Each vial contains 100 micrograms of gonadorelin as gonadorelin hydrochloride.

3. Pharmaceutical Form

Powder and solvent for solution for injection.

4. Clinical Particulars

4.1 Therapeutic Indications

Gonadorelin as a single injection is indicated for evaluating the functional capacity and response of the gonadotropes of the anterior pituitary. The LH/FSH-RH response is used in testing patients with suspected gonadotropin deficiency, whether due to the hypothalamus alone or in combination with anterior pituitary failure. Gonadorelin injection is also indicated for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumour or surgery and/or irradiation.

The gonadorelin test complements the clinical assessment of patients with a variety of endocrine disorders involving the hypothalamic-pituitary axis. In cases where there is a normal response, it indicates the presence of functional pituitary gonadotropes. The single injection test does not determine the patho-physiological cause for the subnormal response and does not measure pituitary gonadotropic reserve.

4.2 Posology And Method Of Administration

Route of administration

For subcutaneous and intravenous administration.

Adults and Elderly

100 micrograms, subcutaneously or intravenously. In females for whom the phase of the menstrual cycle can be established, the test should be performed in the early follicular phase (days 1-7).

Children

Do not use in children under one year as the diluent contains 2% benzyl alcohol.

Test Methodology

To determine the status of the gonadotropin secretory capacity of the anterior pituitary, a test procedure requiring seven venous blood samples for LH/FSH-RH is recommended.

Procedure:

1. Venous blood samples should be drawn at -15 minutes and immediately prior to gonadorelin administration. The LH/FSH-RH baseline is obtained by averaging the LH/FSH-RH values of the two samples.

2. Administer a bolus of gonadorelin subcutaneously or intravenously.

3. Draw venous blood samples at 15, 30, 45, 60 and 120 minutes after administration.

4. Blood samples should be handled as recommended by the laboratory that will determine the LH/FSH-RH content. It must be emphasised that the reliability of the test is directly related to the inter-assay and intra-assay reliability of the laboratory performing the assay.

Interpretation of test results: Interpretation of the LH/FSH-RH response requires an understanding of the hypothalamic-pituitary physiology, knowledge of the clinical status of the individual patient, and familiarity with the normal ranges and the standards used in the laboratory performing the LH/FSH-RH assays.

Curves provided represent the LH/FSH-RH response curves after administration in normal subjects. The normal LH/FSH-RH response curves were established between the 10th percentile (B line) and 90th percentile (A line) of all LH/FSH-RH responses in normal subjects analysed from the results of clinical studies.

Individual patient responses should be plotted on the appropriate curve. A subnormal response in patients is defined as three or more LH/FSH-RH values which fall below the B line of the normal LH/FSH-RH response curve.

In cases where there is a blunted or borderline response, the gonadorelin test should be repeated.

The gonadorellin test complements the clinical assessment of patients with a variety of endocrine disorders involving the hypothalamic-pituitary axis. In cases where there is a normal response, it indicates the presence of functional pituitary gonadotropes. The single injection test does not determine the patho-physiological cause for the subnormal response and does not measure pituitary gonadotropic reserve.

4.3 Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Known or suspected pregnancy.

Do not use in children under one year of age as diluent contains 2% benzyl alcohol.

4.4 Special Warnings And Precautions For Use

Although allergic and hypersensitivity reactions have been observed with other polypeptide hormones, to date no such reactions have been encountered following the administration of a single 100 micrograms dose of gonadorelin used for diagnostic purposes. Rare instances of hypersensitivity reactions have been reported. Therefore, patients treated by intermittent pulsatile therapy in whom re-administration is considered, particularly by the intravenous route, should be carefully observed. Administration during the follicular phase of a normal cycle may result in premature ovulation and appropriate measures are advised to prevent an unwanted pregnancy in these circumstances.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The gonadorelin test should be conducted in the absence of other drugs which directly affect the pituitary secretion of gonadotropins. These would include a variety of preparations which contain androgens, oestrogens, progestogens or glucocorticoids. The gonadotropin levels may be transiently elevated by spironolactone, minimally elevated by methyldopa, and suppressed by oral contraceptives and digoxin. The response to gonadorelin may be blunted by phenothiazines and dopamine antagonists which cause a rise in prolactin.

4.6 Pregnancy And Lactation

Gonadorelin should not be administered to pregnant women or nursing mothers.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Systemic complaints such as headache, nausea, light headedness, abdominal discomfort and flushing have been reported rarely following administration of gonadorelin. Local swelling, occasionally with pain and pruritis at the injection site may occur if gonadorelin is administered subcutaneously. Local and generalised skin rash have been noted after chronic subcutaneous administration.

Thrombophlebitis with septicaemia, mild and severe, has been reported in isolated cases at the site of intravenous injection. Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing, urticaria, swelling, itching and redness of the face, eyelids and lips, induration at injection site) have been reported following multiple-dose administration of large doses. Antibody formation has also been reported rarely after chronic administration of large doses.

4.9 Overdose

Gonadorelin has been administered parenterally in doses up to 3 mg bd for 28 days without any signs or symptoms of overdosage. In cases of overdosage or idiosyncrasy, symptomatic treatment should be administered as required.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Gonadorelin stimulates the synthesis of follicle stimulating hormone and luteinising hormone in the anterior lobe of the pituitary as well as their release.

5.2 Pharmacokinetic Properties

Gonadorelin is rapidly hydrolysed in plasma and excreted in urine with a half life of about 4 minutes.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Lactose monohydrate USP

Solvent:

Benzyl alcohol BP

Water for injections BP

6.2 Incompatibilities

Gonadorelin should not be mixed with any other substance.

6.3 Shelf Life

Unopened: 48 months

After reconstitution: 24 hours

6.4 Special Precautions For Storage

Store below 25°C.

6.5 Nature And Contents Of Container

Gonadorelin is supplied in a USP Type I clear glass vial with grey butyl rubber stopper and aluminium collar. The sterile solvent is 5 ml water for injections with 2% benzyl alcohol supplied in a Ph.Eur. Type I clear glass ampoule.

6.6 Special Precautions For Disposal And Other Handling

Preparation for single injection administration: Reconstitute 100 micrograms vial with 1.0 ml of the accompanying sterile solvent of 2 % benzyl alcohol. Prepare solution immediately before use. After reconstitution, refrigerate and use within 1 day. Discard unused reconstituted solution and solvent.

7. Marketing Authorisation Holder

Intrapharm Laboratories Limited

Kidwells Park House

Kidwells Park Drive

Maidenhead

Berkshire SL6 8AQ

United Kingdom

8. Marketing Authorisation Number(S)

PL 17509/0005.

9. Date Of First Authorisation/Renewal Of The Authorisation

Date of first authorisation: 25 May 2001

Date of latest renewal: 26 June 2004

10. Date Of Revision Of The Text

11 March 2010.

11 DOSIMETRY

IF APPLICABLE

12 INSTRUCTIONS FOR PREPARATION OF RADIOPHARMACEUTICALS

IF APPLICABLE